Heparin Injection (5000IU/10mg)
SKU: COLP
Brand: Amazon Laboratories
৳590
Variant:
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Heparin is an anticoagulant which prevents abnormal clotting of blood. It not only prevents the formation of harmful blood clots in the legs, lungs, and heart but also stops them from growing bigger. Heparin is administered under the supervision of a doctor. Your doctor will decide how often you should take this medicine. This may change from time to time depending on how well it is working. You should take this medicine regularly to get the most benefit, even if you feel fine. It is preventing future harm. Your doctor may get regular blood tests done to make sure this medicine is working well and monitor the levels of potassium and platelets. Use of this medicine may increase your risk of bleeding. Let your doctor know immediately if you see pinpoint rash or blood in your vomits, urine, or stool. You should be careful while shaving, cutting nails, using sharp objects, or engaging in contact sports. You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it.
Uses of Heparin
- Blood clots
How to use Heparin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Heparin works
Heparin is an anticoagulant. It works by preventing the formation of harmful blood clots. Although it does not dissolve the existing blood clots, it prevents them from growing larger and causing blockages in the blood vessels.
What if you forget to take Heparin?
If you miss a dose of Heparin, please consult your doctor.
Quick Tips
- Notify your doctor if you see blood in your urine or stool or any unusual bleeding from your skin, gums or nose.
- Inform your doctor if you experience rash, itching, swelling of the face, tongue, and throat while you receive this medicine.
Brief Description
Indication
Atrial fibrillation, Acute coronary syndrome, Unstable angina, Pulmonary embolism, Thromboembolism, Deep-vein thrombosis, Cardiopulmonary bypass, Hemofiltration, Peripheral arterial embolism
Administration
IV Preparation Recommended infusion concentration for most patients is 25,000 units in 500 mL D5W (50 units/mL premixed infusion solution) IV Administration IV injection may be given undiluted or diluted in 50-100 mL NS or D5W Infusion: Dilute in NS, D5W, or other compatible fluid Continuous IV therapy is preferred because intermittent IV therapy produces a higher incidence of bleeding abnormalities
Adult Dose
DVT & Pulmonary Embolism Prophylaxis 5000 units Subcutaneous(SC) q8-12hr, OR 7500 units SC q12hr Treatment 80 units/kg IV bolus, THEN continuous infusion of 18 units/kg/hr, OR 5000 units IV bolus, THEN continuous infusion of 1300 units/hr, OR 250 units/kg (alternatively, 17,500 units) SC, THEN 250 units/kg q12hr Acute Coronary Syndromes PCI Without GPIIb/IIIa inhibitor: Initial IV bolus of 70-100 units/kg (target ACT 250-300 sec) With GPIIb/IIIa inhibitor: Initial IV bolus of 50-70 units/kg (target ACT >200 sec) STEMI Patient on fibrinolytics: IV bolus of 60 units/kg (max: 4000 units), THEN 12 units/kg/hr (max 1000 units/hr) as continuous IV infusion Dose should be adjusted to maintain aPTT of 50-70 sec Unstable Angina/NSTEMI Initial IV bolus of 60-70 units/kg (max: 5000 units), THEN initial IV infusion of 12-15 units/kg/hr (max: 1000 units/hr) Dose should be adjusted to maintain aPTT of 50-70 sec Anticoagulation Intermittent IV injection 8000-10,000 units IV initially, THEN 50-70 units/kg (5000-10,000 units) q4-6hr Continuous IV infusion 5000 units IV injection, followed by continuous IV infusion of 20,000-40,000 units/24 hr Catheter Patency Prevention of clot formation within venous and arterial catheters Use 100 units/mL; instill enough volume to fill lumen of catheter
Child Dose
Venous Thromboembolic Prophylaxis 100-150 units/kg IV once Venous Thromboembolic Treatment <1 year Loading dose of 75 units/kg IV, THEN 28 units/kg/hr IV as initial maintenance dose >1 year Loading dose of 75 units/kg IV, THEN 20 units/kg/hr IV as initial maintenance dose I ntermittent IV injection Initially give 50-100 units/kg IV infusion, THEN 100 units/kg IV infusion q4hr as a maintenance dose
Contraindication
Patients predisposed to active bleeding including thrombocytopenia, peptic ulcer disease, cerebrovascular disorders, haemorrhagic blood disorders, bacterial endocarditis, severe hypertension, oesophageal varices. Recent surgery at sites where haemorrhage would be an especial risk. Severe renal and hepatic impairment. Cerebral or subarachnoid haemorrhage, abdominal or thoracic bleeding into closed space, severe traumatic bleed, hepatic, renal, splenic or arterial injury, severe haemostatic defect, arterial thrombosis with heparin-associated thrombocytopenia. IM admin.
Mode of Action
Heparin increases the inhibitory action of antithrombin III (AT III) on clotting factors XIIa, XIa, IXa, Xa and thrombin. This inhibits the conversion of prothrombin to thrombin and fibrinogen to fibrin. It also inhibits platelet function. It may reduce the activity of ATIII at very high doses.
Precaution
Monitor platelet counts. Discontinue treatment if thrombocytopenia occurs. Hypersensitivity, elderly, pregnancy. Lactation: Not excreted in breast milk; compatible
Side Effect
>10% Heparin-induced thrombocytopenia, possibly delayed (10-30% ) Frequency Not Defined Mild pain,Hematoma,Hemorrhage,Local irritation,Erythema,Injection site ulcer (after deep SC injection),Increased liver aminotransferase,Anaphylaxis,Immune hypersensitivity reaction,Osteoporosis (long-term, high-dose use) Potentially Fatal: Heparin-induced thrombocytopenia with or without thrombosis; bleeding.
Interaction
Enhanced anticoagulant effect w/ other drugs affecting platelet function or the coagulation system (e.g. platelet aggregation inhibitors, thrombolytic agents, salicylates, NSAIDs, vit K antagonists, dextrans, activated protein C). Decreased anticoagulant effect w/ gyceryl trinitrate infusion. Increased risk of hyperkalaemia w/ ACE inhibitors or angiotensin II antagonists.
